The Hypocritic Oath

Preach, Sistuh!

Posted in Uncategorized by trinkwasser on August 26, 2009

Conclusions:

In postmenopausal women with relatively low total fat intake, a greater saturated fat intake is associated with less progression of coronary atherosclerosis, whereas carbohydrate intake is associated with a greater progression.

Taken from this paper

Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women

Dariush Mozaffarian, Eric B Rimm, and David M Herrington

We also evaluated the relations of other major dietary nutrients with atherosclerotic progression.

Polyunsaturated fat intake was positively associated with a decline in mean minimal coronary artery diameter (P for trend = 0.04). Carbohydrate intake was strongly positively associated with progression, with a 19-mm greater decline in mean minimal coronary artery diameter in a comparison of extreme quartiles of intake (P for trend = 0.001). Mono-unsaturated fat, total fat, and protein intakes were not associated with progression

Carbohydrate intake was associated with greater atherosclerotic progression when replacing saturated fat (P = 0.04) and with a trend toward greater atherosclerotic progression when replacing monounsaturated fat (P = 0.09). Poly-unsaturated fat intake was associated with greater atherosclerotic progression when replacing saturated fat (P = 0.02).

A greater saturated fat intake was associated with other lipid differences, including higher HDL, higher HDL2, higher apoprotein A-I, lower triacylglycerol concentrations, and a lower TC:HDL cholesterol ratio. These findings are consistent with those of experimental studies that showed unfavorable effects of low-fat, low-saturated-fat diets on HDL cholesterol, HDL2 cholesterol, the TC:HDL cholesterol ratio, and postprandial triacyl-glycerol concentrations in women,  particularly when compared with men

Carbohydrate intake was positively associated with atherosclerotic progression when replacing saturated fat and monounsaturated fat but not when replacing total fat, polyunsaturated fat, or protein.

Polyunsaturated fat intake was not associated with atherosclerotic progression when replacing carbohydrate or protein but was positively associated when replacing other fats, especially saturated fat.

Although CHD is the leading cause of death among both men and women, prior studies have historically focused on relations between risk factors and CHD in men. Our findings are not consistent with the hypothesis—based largely on observations in men—that saturated fat intake increases atherosclerotic progression in postmenopausal women but instead suggest that saturated fat intake may reduce such progression, especially when mono-unsaturated fat intake is low or carbohydrate intake is high. Our findings also suggest that carbohydrate intake may increase atherosclerotic progression, especially when refined carbohydrates replace saturated or monounsaturated fats. Confirmation of these findings in other studies and examination of potential mechanisms and alternative explanations are warranted.

I’ve pulled these quotes: the whole paper is well worth a read: one in the eye for the lipophobes! Admittedly this study was on a fairly specific population and as the authors point out most such studies are done on men. There’s a long list of references that also look interesting

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: